Research indicates that protein presence can significantly impact the antimicrobial efficacy of these agents. This phenomenon, often referred to as 'protein error', arises from chemical and ionic interactions between proteins and antimicrobial agents, potentially diminishing their effectiveness.

In a recent study, the antimicrobial efficacies of seven commercially available wound irrigation solutions were evaluated, each featuring different active agents. Among these, five solutions contained hypochlorous acid (HOCl), one featured octenidine (OCT), and another utilized polyhexamethylene biguanide (PHMB). This study aimed to assess antimicrobial efficacy in a simulated wound environment with varying protein concentrations.

Findings Under Low Protein Conditions

In the low protein scenario, a 0.85% NaCl solution was used as a negative control, demonstrating minimal bacterial reduction. Notably, the PHMB-based product achieved an impressive 5-log reduction against Staphylococcus aureus within just 60 seconds of contact. Conversely, all five HOCl-based products required a full 2 minutes to achieve a 5-log reduction, underscoring variability in efficacy. 

Findings Under High Protein Conditions

When the protein concentration was increased, the results were striking. The PHMB-based solution maintained its efficacy, achieving a 5-log reduction at a 2-minute contact time. In contrast, none of the HOCl-based products surpassed a 3.5-log reduction, even after an extended contact time of 30 minutes. This highlights the significant impact of protein interference on the bactericidal activity of HOCl-based solutions compared to PHMB-based options.

The Role of Prontosan® by B. Braun

In this context, Prontosan^®, a product from B. Braun, emerges as a robust solution for wound management. Formulated with a unique blend of surfactants and active ingredients, Prontosan® effectively cleanses wounds while maintaining high antimicrobial efficacy even in challenging environments with elevated protein levels. Its ability to manage biofilm and provide sustained antimicrobial action makes it an ideal choice for healthcare professionals dealing with chronic wounds. 

Conclusion

The evaluation of these commercially available wound irrigation solutions demonstrates that while HOCl-based products are widely used, their efficacy can be markedly reduced in high protein environments. This finding underscores the importance of selecting appropriate wound care solutions tailored to the wound's protein load, particularly in clinical settings where chronic wounds are prevalent.

With products like Prontosan®, B. Braun offers an advanced solution that not only addresses these challenges but also enhances patient outcomes through effective wound management.